Search results for "DNA repair genes"

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Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients.

2006

Abstract Background: Impaired DNA repair capacity may favorably affect survival in cisplatin/gemcitabine-treated non-small-cell lung cancer (NSCLC) patients. We investigated the association of survival with genetic polymorphisms in X-ray repair cross-complementing group 1 and group 3 (XRCC3), xeroderma pigmentosum group D (XPD), excision repair cross-complementing group 1, ligase IV, ribonucleotide reductase, TP53, cyclooxygenase-2, interleukin-6, peroxisome proliferator-activated receptor γ, epidermal growth factor, methylene-tetra-hydrofolate reductase and methionine synthase. Patients and methods: One hundred and thirty-five stage IV or IIIB (with malignant pleural effusion) NSCLC patien…

Xeroderma pigmentosumLung NeoplasmsDNA RepairGenotypeDeoxycytidineXRCC1Carcinoma Non-Small-Cell LungAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansCisplatin; DNA repair genes; Gemcitabine; Non-small-cell lung cancer; Polymorphisms; XRCC3Lung cancerXRCC3Survival analysisCisplatinPolymorphism GeneticDNA repair genesbusiness.industryHazard ratioHematologymedicine.diseaseSurvival AnalysisGemcitabineGemcitabineOncologyCancer researchCisplatinbusinessPolymorphismsNon-small-cell lung cancerNucleotide excision repairmedicine.drugAnnals of oncology : official journal of the European Society for Medical Oncology

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